Getting Started With XARELTO®

Adding XARELTO®to low-dose aspirin

Beginning a new medication can feel like a big commitment. But with a few tips and ongoing support, it’s possible to start on the right track—for yourself and for those who care about you. First things first, be sure to fill your XARELTO® prescription if you haven’t yet. Keep reading to learn more about XARELTO®, how to take it, and what to do if you miss a dose.

What is XARELTO®?

XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has few drug interactions, no known dietary restrictions, and you don’t need to have frequent blood tests to see if XARELTO® is working.

How does XARELTO® work with low-dose aspirin?

Both XARELTO® and low-dose aspirin help prevent serious blood clots from forming and growing—but they work in different ways:

  • XARELTO® works by slowing down the blood’s clotting process. It does this by selectively targeting just one critical factor needed for blood to clot—Factor Xa.
  • Aspirin is an antiplatelet blood thinner that works by helping to keep platelets (which are pieces of blood cells) from sticking together and forming blood clots.

XARELTO® for People With CAD

XARELTO®, when taken with low-dose aspirin, helps further reduce the risk of heart attack, stroke, and cardiovascular death in people with chronic CAD.

almost 96% Did not have
a cardiovascular

In a clinical trial,

almost 96% of people did not have a heart attack or stroke, or die from a cardiovascular event.*

*Patients were followed for an average length of treatment of 23 months.

Remember, all blood thinners come with a risk of bleeding. Around 3% of people taking XARELTO® 2.5 mg twice daily in combination with low-dose aspirin experienced a major bleeding event, such as bleeding into the brain. That represents about a 1% increase in bleeding versus people taking only aspirin.

How to take XARELTO®

Take XARELTO® 2.5 mg twice daily with or without food in combination with aspirin 75 mg–100 mg once daily as instructed by your healthcare professional.

What to do if you miss a dose:

  • If you miss a dose of XARELTO®, take your next 2.5 mg dose at your regularly scheduled time.

Important things to keep in mind:

Do not stop taking XARELTO® unless your healthcare professional tells you to. Stopping XARELTO® suddenly may increase your risk for blood clots that can cause a heart attack or stroke.

Take XARELTO® and aspirin exactly as prescribed by your healthcare professional.

Tell all the healthcare professionals you see, including your dentist, that you’re taking XARELTO®. They should talk to the healthcare professional who prescribed XARELTO® before any surgical, medical, or dental procedure. You may need to stop taking it for a short time before and after the procedure.

Tell your healthcare professional about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Get Savings and Support for XARELTO®

Once you and your doctor have decided that XARELTO® is right for you, Janssen CarePath will help you find the resources you may need to get started and stay on track.

Paying for XARELTO®

At Janssen, we don’t want cost to get in the way of treatment you need. We can help you explore options to lower your out-of-pocket cost for XARELTO®.

If you have commercial or private health insurance and need help paying for XARELTO®, the Janssen CarePath Savings Program may be able to help.

If you are using a government-funded healthcare program to pay for your medication or have no insurance coverage and need help paying for XARELTO®, Janssen CarePath can provide information about other resources that may be able to help you with your out-of-pocket medication costs.

Did you know? XARELTO® is covered by 94% of commercial and Medicare plans.

Support for XARELTO®

Find more information about the following options as you get started taking XARELTO®:

  • Get started with the Janssen CarePath Trial Offer for XARELTO®

    Terms expire at the end of each calendar year and may change. Program requirements apply.
    Learn More

  • Sign up for Ongoing Educational Support

    Get the latest info by signing up for Ongoing Educational Support for XARELTO®. You’ll receive tailored communications from Janssen CarePath in your inbox and mailbox that will help you:

    • Learn more about your condition and why it comes with a risk of blood clots
    • Understand treatment options like XARELTO®, and how XARELTO® works to help protect you from serious blood clot–related events
    • Set and keep health goals related to your condition
    • Discover ideas to support your path toward heart-healthy living
    • Continue taking XARELTO® with tools like daily medication reminders and personalized refill reminders

Where can I learn more?

  • Watch a video from the Clot Wise™ Education Program. This animated video narrated by a physician can help you learn more about how XARELTO® works with aspirin to help reduce your risk of serious heart problems related to CAD.
  • Visit for information about CAD and XARELTO®.