Getting Started With XARELTO®


Beginning a new medication can feel like a big commitment. But with a few tips and ongoing support, it’s possible to start on the right track—for yourself and for those who care about you. First things first, be sure to fill your XARELTO® prescription if you haven’t yet. Keep reading to learn more about XARELTO®, how to take it, and what to do if you miss a dose.

What is XARELTO®?

XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has few drug interactions, no known dietary restrictions, and you don’t need to have frequent blood tests to see if XARELTO® is working.

How does XARELTO® work?

XARELTO® works by slowing down the blood’s clotting process. It does this by selectively targeting just one critical factor needed for blood to clot—Factor Xa. This means XARELTO® interacts with less of your body’s natural blood-clotting function than older medicines like warfarin.*

*Coumadin® and Jantoven® are brand names for warfarin.

Third-party trademarks used herein are trademarks of their respective owners.

Treating DVT and PE with XARELTO®

During your treatment, XARELTO® helps keep DVT and PE blood clots from growing larger and helps prevent new ones.

The dosing of XARELTO® is higher in the first 21 days to help protect you during the period when your risk for having another blood clot is the highest. After 21 days, you’ll switch to taking a lower dose of XARELTO®.

almost98%Did not have
another dvt or pe*

In clinical studies,

almost 98% of people taking XARELTO® did not have another DVT or PE.*

*Patients were followed for an average length of treatment of 208 days.

Remember, all blood thinners come with a risk of bleeding. Clinical studies with people taking XARELTO® to treat a DVT or PE showed that they had less major bleeding than those being treated with enoxaparin and warfarin*—1% with XARELTO® vs 1.7% with enoxaparin and warfarin.

*Coumadin® and Jantoven® are brand names for warfarin.

How to take XARELTO®

  • Start with one XARELTO® 15-mg tablet twice a day with food for 21 days.
  • On day 22, switch to one XARELTO® 20-mg tablet once a day with food.

What to do if you miss a dose:

  • If you take XARELTO® twice a day and miss a dose, take it as soon as you remember on the same day. You may take 2 doses at the same time to make up for the missed dose. Take your next dose at your regularly scheduled time.
  • If you take XARELTO® once a day and miss a dose, take it as soon as you remember on the same day. Take your next dose at your regularly scheduled time.

Important things to keep in mind:

Do not change your dose or stop taking XARELTO® unless your healthcare professional tells you to. Stopping XARELTO® increases your risk of having another DVT or PE blood clot.

Take XARELTO® exactly as prescribed by your healthcare professional.

Tell all the healthcare professionals you see, including your dentist, that you’re taking XARELTO®. They should talk to the healthcare professional who prescribed XARELTO® before any surgical, medical, or dental procedure. You may need to stop taking it for a short time before and after the procedure.

Tell your healthcare professional about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Helpful tip

Set a reminder to switch your dose on day 22 of your treatment. Put it in your smartphone calendar or reminder app, or leave a note for yourself where you know you’ll see it.

Get Savings and Support for XARELTO®

Once you and your doctor have decided that XARELTO® is right for you, Janssen CarePath will help you find the resources you may need to get started and stay on track.

Paying for XARELTO®

At Janssen, we don’t want cost to get in the way of treatment you need. We can help you explore options to lower your out-of-pocket cost for XARELTO®.

If you have commercial or private health insurance and need help paying for XARELTO®, the Janssen CarePath Savings Program may be able to help.

If you are using a government-funded healthcare program to pay for your medication or have no insurance coverage and need help paying for XARELTO®, Janssen CarePath can provide information about other resources that may be able to help you with your out-of-pocket medication costs.

Did you know? XARELTO® is covered by 94% of commercial and Medicare plans.

Support for XARELTO®

Find more information about the following options as you get started taking XARELTO®:

  • Get started with the Janssen CarePath Trial Offer for XARELTO®

    Terms expire at the end of each calendar year and may change. Program requirements apply.
    Learn More

  • Sign up for Ongoing Educational Support

    Get the latest info by signing up for Ongoing Educational Support for XARELTO®. You’ll receive tailored communications from Janssen CarePath in your inbox and mailbox that will help you:

    • Learn more about DVT and PE blood clots and why some people have an increased risk for repeat events
    • Understand treatment options like XARELTO®, and how XARELTO® works to help keep you protected
    • Set and keep health goals related to your condition
    • Discover ideas to support your path toward heart-healthy living
    • Continue taking XARELTO® with tools like daily medication reminders and personalized refill reminders

Where can I learn more?

  • Watch a video from the Clot Wise™ Education Program. This animated video narrated by a physician can help you learn more about how XARELTO® works to treat your blood clot and how it helps reduce your risk of having another.
  • Visit for information about DVT or PE and XARELTO®.